This OTJR: Occupation, Participation, and Health journal article describes a study on relationships between these factors and depression in middle-aged adults with physical disabilities during the early stages of the COVID-19 pandemic. The authors also provided recommendations for OTs looking to address symptoms of depression in their clients. Participants in a larger study of people aging with long-term physical disabilities (ages 45–64) completed a supplemental survey with questions about COVID-19, depression, and factors associated with depression.